Genetics of early-onset obsessive-compulsive disorder.

Eur Child Adolesc Psychiatry 2010 Mar 6;19(3):227-35. Epub 2010 Mar 6.

Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.

Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00787-010-0087-7DOI Listing
March 2010
13 Reads

Publication Analysis

Top Keywords

obsessive-compulsive disorder
8
candidate genes
8
ocd
5
promote independent
4
neurotransmitter systems
4
independent replication
4
systems analyzed
4
analyzed total
4
will promote
4
genome-wide linkage
4
three genome-wide
4
total three
4
genes neurotransmitter
4
familial candidate
4
studies consideration
4
seriously impaired
4
ocd seriously
4
impaired development
4
ocd early
4
onset familial
4

Similar Publications