Alcohol Alcohol 2010 May-Jun;45(3):241-6. Epub 2010 Mar 5.
Department of Psychology, Université Catholique de Louvain, Place du Cardinal Mercier 10, B-1348 Louvain-la-Neuve, Belgium.
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Alcohol 2000 Feb;20(2):181-5
Medical University of South Carolina, Alcohol Research Center, Charleston 29425, USA.
Research has demonstrated a relationship between the number of previous alcohol detoxifications and increased severity of the alcohol withdrawal syndrome (AWS) that is hypothesized to be similar to an electrophysiologic "kindling process." Application of a "kindling" model to AWS suggests that neuroadaptation of the central nervous system to repeated detoxifications may also cause neurobehavioral alterations that may affect "craving." This study examined craving as assessed by the Obsessive Compulsive Drinking Scale (OCDS) in 67 adult outpatients meeting DSM-IV criteria (American Psychiatric Association, 1994) for alcohol dependence and AWS having either < 2 and > or = 2 previous detoxifications. Read More
Prog Neuropsychopharmacol Biol Psychiatry 2008 Aug 8;32(6):1574-9. Epub 2008 Jun 8.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029, India.
Objective: Neuropsychological deficits are potential endophenotype markers. In obsessive-compulsive disorder (OCD), there is impairment in executive functions and nonverbal memory. However, studies have largely examined neuropsychological functioning in patients during the symptomatic phase. Read More
Brain Behav Immun 2012 Aug 10;26(6):911-8. Epub 2012 Apr 10.
Department of Adult Psychiatry and Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium.
Background And Aims: Mood and cognition alterations play a role in the motivation for alcohol-drinking. Lipopolysaccharides are known to stimulate inflammation that was shown to induce mood and cognitive changes in rodents and humans. Enhanced intestinal permeability and elevated blood LPS characterize alcohol-dependent mice. Read More
Alcohol Clin Exp Res 2002 Jun;26(6):785-95
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton, United Kingdom.
Background: The increased severity of withdrawal during successive detoxifications from alcohol is well documented for seizures, but the importance of the number of withdrawal events for other withdrawal symptoms such as anxiety and for alcohol craving is not known. Studies in animals are consistent with increases in reinforcing properties of alcohol with a greater number of withdrawal experiences. Thus, we predicted that patients who had undergone multiple detoxifications would show greater desire for alcohol and might experience more anxiety compared with patients with fewer detoxifications or compared with social drinkers. Read More