Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.

PLoS Genet 2010 Feb 26;6(2):e1000856. Epub 2010 Feb 26.

Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom.

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829062PMC
February 2010
38 Reads

Publication Analysis

Top Keywords

tooth development
12
association study
8
genome-wide association
8
tooth
5
time tooth
4
study time
4
performed genome-wide
4
eruption number
4
teeth year
4
number teeth
4
humans performed
4
tooth eruption
4
developmental anomaly
4
abnormalities tooth
4
complex abnormalities
4
craniofacial complex
4
development common
4
common tooth
4
year 4564
4
common developmental
4

Similar Publications