Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains.

Authors:
Jianming Lu
Jianming Lu
Beckman Research Institute of the City of Hope
United States
Celinah Mwakwari
Celinah Mwakwari
Louisiana State University
United States
Kevin M Smith
Kevin M Smith
Louisiana State University
United States

ARKIVOC 2009 May;2010(5):5-16

In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom chain in 1) were synthesized from monopyrrole precursors.

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Source
http://dx.doi.org/10.1901/jaba.2009.2010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783647PMC
May 2009
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