Acid-base balance in amphibian gastric mucosa.

Authors:
Dr. Kaliyamoorthy Jayakumar, M.Sc., M.Phil., Ph.D
Dr. Kaliyamoorthy Jayakumar, M.Sc., M.Phil., Ph.D
Environmental Biology Lab
Traditional Medicinal Plants Researcher
Environmental Biotechnology
Kumbakonam, Tamil Nadu | INDIA
Dr. Husain Hamza Jabbad, FRCSC
Dr. Husain Hamza Jabbad, FRCSC
King Abdulaziz University
Asssociate prof. Cardiovascular and thoracic surgeon
Cardiovascular and thoracic surgery
Jeddah, western province | Saudi Arabia
Dr QA Hashmi, MBBS, FCPS Clinical Oncology
Dr QA Hashmi, MBBS, FCPS Clinical Oncology
Multan Institute Of Nuclear Medicine and Radiotherapy,Multan.
Doctor
Clinical Oncology
Multan, Punjab | Pakistan
Jagadeesan Premanandh
Jagadeesan Premanandh
Dr.
Abu Dhabi, Abu Dhabi | United Arab Emirates
Dr Valerie Urbach, PhD
Dr Valerie Urbach, PhD
INSERM
Dr
cystic fibrosis, lipoxins, resolvins
Paris, Île-de-France | France
Eric Scott Sills, MD PhD
Eric Scott Sills, MD PhD
Gen 5 Fertility Center
Senior VP for Research
Reproductive endocrinology
La Jolla, CALIF | United States
Dr Debprasad Chattopadhyay, Ph.D.
Dr Debprasad Chattopadhyay, Ph.D.
ICMR-Virus Unit
Scientist
Ethnopharmacology, Virology, Microbiology, Molecular Medicine
Kolkata, West Bengal | India
Pr Hafedh Abdelmelek, DVM, PhD
Pr Hafedh Abdelmelek, DVM, PhD
Université de Carthage
Professor
Bioeffects of EMF, Nanosciences, coach start up, conflict management
Jarzouna, Bizerte | Tunisia
Professor Jingyuan Chen, PhD
Professor Jingyuan Chen, PhD
University of Fukui
Professor
3-9-1 Bunkyo, Fukui | Japan
Eka Chkonia
Eka Chkonia
Tbilisi State Medical University
Professor
Tbilisi, Tbilisi | Georgia
Valentin P Reutov
Valentin P Reutov
Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences
PhD, Doctor of Biological Sciences, Professor
Nitric Oxide Cycle, Stress, Neurophysiology and Neuropathology
Moscow | Russian Federation
Dr Leonid R Gavrilov, DSc, PhD
Dr Leonid R Gavrilov, DSc, PhD
N.N. Andreyev Acoustics Institute
Principal Research Scientist
Moscow | Russian Federation
Kristen L Triebel
Kristen L Triebel
University of Alabama at Birmingham
United States
Denbela Hidosa
Denbela Hidosa
Jinka Agricultural Research Center
Associate Researcher
Jinka, SNNP | Ethiopia

Am J Physiol 1975 Sep;229(3):721-30

It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.

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http://dx.doi.org/10.1152/ajplegacy.1975.229.3.721DOI Listing
September 1975
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5 Citations

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