Epilepsia 2010 May 7;51(5):777-82. Epub 2010 Jan 7.
Department of Paediatric Neurology, The Leeds Teaching Hospitals NHS Trust, UK.
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J Invest Dermatol 2018 Sep 20;138(9):2075-2079. Epub 2018 Mar 20.
Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland. Electronic address:
FEBS J 2017 09 20;284(17):2856-2869. Epub 2017 Jul 20.
School of Pharmacy, Shanghai Jiao Tong University, China.
Anterior gradient 2 (AGR2), a member of protein disulfide isomerase (PDI) family, is both located in cytoplasm and secreted into extracellular matrix. The orthologs of AGR2 have been linked to limb regeneration in newt and wound healing in zebrafish. In mammals, AGR2 influences multiple cell signaling pathways in tumor formation and in normal cell functions related to new tissue formation like angiogenesis. Read More
Eur Neurol Rev 2016 ;11(1):20-21
Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, Department of Neurology, New York University School of Medicine, New York, US.
Much of the clinical and research attention for Parkinson's Disease (PD) has focused on mild to moderate stages. As the disease advances, it can become difficult for patients to attend clinical visits. These patients are often lost to follow-up, and consequently, vanish from the pool of potential research subjects who could inform our management of this understudied population. Read More
J Exp Clin Cancer Res 2015 Sep 4;34:92. Epub 2015 Sep 4.
Personalised Healthcare and Biomarkers, AstraZeneca, Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WGT, UK.
Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. Biopsy samples for mutation testing may be taken from primary or metastatic sites, depending on which sample is most accessible, and upon differing diagnostic practices between territories. However, the mutation status concordance between primary tumours and corresponding metastases is the subject of debate. Read More
Indian J Tuberc 2013 Jul;60(3):138-41
JB Tropical Disease Research Centre, MGIMS, Sevagram, India.
Background: Mycobacterial ES-31 serine protease has been reported to be a drug target using protease and lipase inhibitors in axenic and macrophage cultures. Simple screening techniques are needed for rapid testing of anti-tubercular drugs.
Aim: To demonstrate the usefulness of ELISA protocol based on antigenic reactivity of mycobacterial serine protease by indirect ELISA for detecting anti-tubercular activity. Read More