Frequency of bone marrow involvement in Hodgkin's lymphoma on first presentation.

J Coll Physicians Surg Pak 2009 Dec;19(12):768-71

Department of Oncology, Combined Military Hospital, Rawalpindi.

Objective: To determine the frequency of bone marrow involvement in patients of Hodgkin's lymphoma on first presentation at oncology department.

Study Design: Case series.

Place And Duration Of Study: The Oncology Department, Combined Military Hospital, Rawalpindi, from April 2006 to February 2007.

Methodology: Thirty five patients of Hodgkin's lymphoma diagnosed on lymph node biopsy presenting for the first time at Oncology Department, Combined Military Hospital, Rawalpindi were included. They were admitted in the ward and evaluated with history, physical examination and staging investigations. Bone marrow trephine biopsy was performed in all patients. Descriptive statistics were used to analyze data.

Results: On clinical and radiological evaluation, 8 patients (22.9%) had clinical stage (CS), 12 (34.3%) had CS II, 9 (25.7%) had CS III and 6 (17.1%) had CS IV. The microscopic appearance in bone marrow trephine examination showed lymphoma infiltrates in 6 (17.14%) patients and chronic disorder in 29 (82.85%) patients. Among patients with bone marrow infiltration, one had CS II disease, three had CS III disease and two had CS IV disease. One patient had bone marrow infiltration as the only manifestation of disease.

Conclusion: Bone marrow involvement was seen in patients with Hodgkin's lymphoma clinical stage II or higher.

Download full-text PDF

Source
http://dx.doi.org/12.2009/JCPSP.768771DOI Listing
December 2009

Publication Analysis

Top Keywords

bone marrow
28
hodgkin's lymphoma
16
patients hodgkin's
12
marrow involvement
12
marrow infiltration
8
clinical stage
8
marrow trephine
8
patients
8
lymphoma presentation
8
involvement patients
8
military hospital
8
oncology department
8
hospital rawalpindi
8
frequency bone
8
department combined
8
combined military
8
marrow
7
bone
6
lymphoma
5
evaluation patients
4

Similar Publications