Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review.

Int J Pediatr 2009 16;2009:348507. Epub 2009 Sep 16.

Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/muL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the initiation of highly active antiretroviral therapy (HAART), the MRI showed progressive white matter lesions with asymmetrical deep and subcortical white matter lesions over the left frontotemporoparietal region and the right frontal lobe. Immune Reconstitution Inflammatory Syndrome (IRIS) was suspected, and the patient was treated with methylprednisolone. His clinical symptoms worsened and despite therapy the patient deteriorated.

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http://www.hindawi.com/journals/ijpedi/2009/348507/
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http://dx.doi.org/10.1155/2009/348507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778135PMC
July 2011
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References

(Supplied by CrossRef)

Journal of Infectious Diseases 1973

Arquivos de Neuro-Psiquiatria 1997

AIDS 1992

Pediatric Infectious Disease Journal 1989

Journal of Child Neurology 2004

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