Lab Chip 2009 Dec 12;9(24):3599-603. Epub 2009 Oct 12.
HSG-IMIT - Institut für Mikro- und Informationstechnik, Wilhelm-Schickard-Strasse 10, D-78052 Villingen-Schwenningen, Germany.
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Lab Chip 2012 Aug 13;12(16):2894-902. Epub 2012 Jun 13.
Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin 9, Ireland.
In this article we introduce a novel technology that utilizes specialized water dissolvable thin films for valving in centrifugal microfluidic systems. In previous work (William Meathrel and Cathy Moritz, IVD Technologies, 2007), dissolvable films (DFs) have been assembled in laminar flow devices to form efficient sacrificial valves where DFs simply open by direct contact with liquid. Here, we build on the original DF valving scheme to leverage sophisticated, merely rotationally actuated vapour barriers and flow control for enabling comprehensive assay integration with low-complexity instrumentation on "lab-on-a-disc" platforms. Read More
Lab Chip 2015 Aug;15(16):3358-69
Centre for Innovation in Medical Engineering(CIME), Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Centrifugal microfluidic systems utilize a conventional spindle motor to automate parallel biochemical assays on a single microfluidic disk. The integration of complex, sequential microfluidic procedures on these platforms relies on robust valving techniques that allow for the precise control and manipulation of fluid flow. The ability of valves to consistently return to their former conditions after each actuation plays a significant role in the real-time manipulation of fluidic operations. Read More
Conf Proc IEEE Eng Med Biol Soc 2013 ;2013:5509-12
One of the main challenges faced by researchers in the field of microfluidic compact disc (CD) platforms is the control of liquid movement and sequencing during spinning. This paper presents a novel microfluidic valve based on the principle of liquid equilibrium on a rotating CD. The proposed liquid equilibrium valve operates by balancing the pressure produced by the liquids in a source and a venting chamber during spinning. Read More
Lab Chip 2015 Jun;15(11):2400-11
National Research Council of Canada, 75 de Mortagne, Boucherville, Quebec J4B 6Y4, Canada.
This paper reports a novel method of controlling liquid motion on a centrifugal microfluidic platform based on the integration of a regulated pressure pump and a programmable electromechanical valving system. We demonstrate accurate control over the displacement of liquids within the system by pressurizing simultaneously multiple ports of the microfluidic device while the platform is rotating at high speed. Compared to classical centrifugal microfluidic platforms where liquids are solely driven by centrifugal and capillary forces, the method presented herein adds a new degree of freedom for fluidic manipulation, which represents a paradigm change in centrifugal microfluidics. Read More