microRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance.

Genes Chromosomes Cancer 2010 Mar;49(3):193-203

Clinic of Medicine I, Medical University of Vienna, Vienna, Austria.

Acute myeloid leukemia (AML) is a malignant disease of hematopoietic cells whose emergence, course, and prognosis is affected by specific recurrent genetic alterations like chromosome aberrations and point mutations, as well as by changes in the expression of certain genes. In the past 2 years, microRNAs (miRNAs)--a novel class of small RNA molecules involved in posttranscriptional gene regulation--have also been shown to be aberrantly expressed in AML. Furthermore, specific miRNA expression patterns were found to be associated with certain genetic and cytogenetic alterations in this disease, and two studies identified miRNAs whose expression levels were predictive of survival. Interestingly, the results of these analyses showed only very limited congruence. This review summarizes published reports on the expression patterns of miRNAs in AML, and discusses possible reasons for the differences in their results.

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.20740DOI Listing
March 2010
14 Reads

Publication Analysis

Top Keywords

expression patterns
12
myeloid leukemia
8
acute myeloid
8
expression
5
micrornas mirnas--a
4
interestingly analyses
4
years micrornas
4
genes years
4
small rna
4
mirnas--a novel
4
class small
4
expression genes
4
novel class
4
survival interestingly
4
well changes
4
aberrations point
4
congruence review
4
disease studies
4
alterations chromosome
4
point mutations
4

Similar Publications