Mapping human genetic diversity in Asia.

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Science 2009 Dec;326(5959):1541-5

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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http://dx.doi.org/10.1126/science.1177074DOI Listing
December 2009
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References

(Supplied by CrossRef)
Article in Science
Li et al.
Science 2008
Article in American journal of human genetics
Kayser et al.
American journal of human genetics 2008

Rosenberg et al.
2005
Article in Science
Rosenberg et al.
Science 2002
Article in Nature; Physical Science (London)
Novembre et al.
Nature; Physical Science (London) 2008

Nelis et al.
2009

Tian et al.
2008
Article in Current biology : CB
Lao et al.
Current biology : CB 2008
Article in Nature; Physical Science (London)
Nature; Physical Science (London) 2003

2000
Article in Genetic epidemiology
Tang et al.
Genetic epidemiology 2005

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