Biochem Pharmacol 2021 Feb 19:114479. Epub 2021 Feb 19.
Department of Physiology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, 250012, P.R. China; Provincial Key Lab of Mental Disorders, Shandong University, Jinan, Shandong, 250012, P.R. China. Electronic address:
Vincristine is widely used in treatment of various malignant tumors. The clinical application of vincristine is accompanied by peripheral neurotoxicity which might not be strictly related to the mechanism of anti-tumor action. There are several possible mechanisms but the effect of vincristine on enteric neurons and the underlying mechanism are still unclear. Read More