Microbiology 2010 Feb 12;156(Pt 2):287-301. Epub 2009 Nov 12.
Center for Ecogenomics, Biodesign Institute, Arizona State University, Tempe, AZ 85287-6501, USA.
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Curr Opin Chem Biol 2009 Dec;13(5-6):532-8
RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan.
Understanding cellular metabolic systems is vital not only for determining the function of enzymatic genes, but also for elucidating the coordination among various metabolic pathways. In this context, high-throughput experiments can provide us with essential, albeit only partial information. Integration of metabolite profiling with other multiple 'omics' data (e. Read More
Mutat Res 2002 Jan;499(1):13-25
Miami Valley Laboratories, The Procter & Gamble Co., P.O. Box 538707, Cincinnati, OH 45253, USA.
The unprecedented advances in molecular biology during the last two decades have resulted in a dramatic increase in knowledge about gene structure and function, an immense database of genetic sequence information, and an impressive set of efficient new technologies for monitoring genetic sequences, genetic variation, and global functional gene expression. These advances have led to a new sub-discipline of toxicology: "toxicogenomics". We define toxicogenomics as "the study of the relationship between the structure and activity of the genome (the cellular complement of genes) and the adverse biological effects of exogenous agents". Read More
Essays Biochem 2008 ;45:67-81
Department of Biochemistry and Molecular Biology and Institute of Biomedicine of University of Barcelona (IBUB), Faculty of Biology, University of Barcelona, Avda, Diagonal, 645, Edifici Nou, pl -2, 08028 Barcelona, Spain.
Systems biology is based on the understanding that the behaviour of the whole is greater than would be expected from the sum of its parts. Thus the ultimate goal of systems biology is to predict the behaviour of the whole system on the basis of the list of components involved. Recent advances in '-omics' technologies and the development of new computational techniques and algorithms have greatly contributed to progress in this field of biology. Read More
Crit Rev Biotechnol 2007 Apr-Jun;27(2):63-75
Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University. Washington, DC, USA.
Recent advances in high-throughput technologies enable quantitative monitoring of the abundance of various biological molecules and allow determination of their variation between biological states on a genomic scale. Two popular platforms are DNA microarrays that measure messenger RNA transcript levels, and gel-free proteomic analyses that quantify protein abundance. Obviously, no single approach can fully unravel the complexities of fundamental biology and it is equally clear that integrative analysis of multiple levels of gene expression would be valuable in this endeavor. Read More