A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expression of the L-selectin ligand or molecular markers of endometrial receptivity.

Authors:
Wilder Alberto Palomino
Wilder Alberto Palomino
Departamento de Obstetricia y Ginecología Campus Centro
Paulina Kohen
Paulina Kohen
Hospital Clínico San Borja-Arriarán
Chile
Luigi Devoto
Luigi Devoto
Hospital Clínico San Borja-Arriarán
Chile

Fertil Steril 2010 Oct 11;94(5):1589-94. Epub 2009 Nov 11.

Instituto de Investigaciones Materno Infantil, Universidad de Chile, Santiago de Chile, Chile.

Objective: To examine the effects of a single-dose of 1.5 mg of levonorgestrel (commonly used as emergency contraceptive) on endometrial receptivity biomarkers through the oral or vaginal route.

Design: Prospective randomized single-blinded trial.

Setting: Affiliated Hospital and University Research Center.

Patient(s): Fertile normal women previously sterilized by tubal ligation.

Intervention(s): Levonorgestrel (1.5 mg) was administered on the day of LH surge either orally (n = 14) or vaginally (n = 13).

Main Outcome Measure(s): Molecular assessment of endometrial progesterone receptors, L-selectin ligand, glicodelin-A and αvβ3 integrin by Immunohistochemistry and reverse transcriptase-polymerase chain reaction.

Result(s): Plasma progesterone concentration and endometrial dating were not different. The pattern of progesterone receptors and glycodelin-A expression was not affected during the early and midsecretory phase. Some endometrial biopsies from the group in which levonorgetrel was orally administered showed areas of glandular atrophy and stromal decidualization. However, the expression of the progesterone receptor, L-selectin ligand, αvβ3 integrin, and glycodelin-A were not different between the groups.

Conclusion(s): Levonorgestrel, given as emergency contraceptive on the day of LH surge, does not disrupt either ovulation or progesterone production by the corpus luteum. The contraceptive mechanism of levonorgestrel at the time of LH surge does not include changes in the progesterone receptors or the endometrial receptivity biomarkers.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2009.09.013DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
October 2010
13 Reads

Publication Analysis

Top Keywords

progesterone receptors
12
emergency contraceptive
12
l-selectin ligand
12
endometrial receptivity
12
receptivity biomarkers
8
levonorgestrel emergency
8
αvβ3 integrin
8
day surge
8
progesterone
6
endometrial
6
levonorgestrel
5
concentration endometrial
4
progesterone concentration
4
chain reactionresults
4
endometrial dating
4
plasma progesterone
4
reactionresults plasma
4
pattern progesterone
4
early midsecretory
4
midsecretory phase
4

Similar Publications