Arch Gen Psychiatry 2009 Nov;66(11):1189-200
Institut d'Alta Tecnologia-Parc de Recerca Biomèdica de Barcelona, Centro Radiológico Computerizado Corporació Sanitària, Barcelona, Spain.
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JAMA Psychiatry 2013 Jun;70(6):619-29
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Importance: Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties.
Objectives: To determine regions of abnormal degree connectivity in patients with OCD and to investigate whether connectivity measures are affected by antidepressant medication in OCD.
Design: Case-control cross-sectional study using resting-state functional magnetic resonance imaging and a data-driven, model-free method to test for alterations in the degree of whole-brain, distant, and local connectivity in unmedicated patients with OCD compared with healthy controls. Read More
Eur Psychiatry 2011 Oct 9;26(7):463-9. Epub 2010 Nov 9.
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part of several neural circuits, including the orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at a network level in non-medicated patients with OCD. Read More
Arch Gen Psychiatry 2007 Aug;64(8):946-55
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia.
Context: The medial frontal cortex (MFC), including the dorsal anterior cingulate and the supplementary motor area, is critical for adaptive and inhibitory control of behavior. Abnormally high MFC activity has been a consistent finding in functional neuroimaging studies of obsessive-compulsive disorder (OCD). However, the precise regions and the neural alterations associated with this abnormality remain unclear. Read More
Arch Gen Psychiatry 2012 Jul;69(7):741-9
Institut d’Alta Tecnologia–Parc de Recerca Biomèdica de Barcelona, Centro Radiológico Computerizado, Barcelona, Spain.
Context: Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD). Recent advances in social cognitive neuroscience suggest that a compelling relationship may exist between this disorder-relevant processing bias and the functional activity of brain regions implicated in OCD.
Objective: To test the hypothesis that patients with OCD demonstrate an increased response of relevant ventromedial prefrontal and orbitofrontal cortex regions in a functional magnetic resonance imaging study of difficult moral decision making. Read More