Angiogenic study in Graves' disease treated with thyroid arterial embolization.

Authors:
Wei Zhao
Wei Zhao
School of Public Health
New Haven | United States
Zhi-Yong Liu
Zhi-Yong Liu
Changhai Hospital
China
Gen-Fa Yi
Gen-Fa Yi
Peking University School and Hospital of Stomatology
China
Li-Juan Shen
Li-Juan Shen
Kunming Medical College
China
Hui-Ying Yang
Hui-Ying Yang
Kunming Medical College
China
Hong Li
Hong Li
Research Center for Brain Function and Psychological Science
China
Dian-Ping Song
Dian-Ping Song
Kunming Medical College
China

Clin Invest Med 2009 Oct 1;32(5):E335-44. Epub 2009 Oct 1.

Kunming Medical College, Kunming, People's Republic of China.

Purpose: To investigate angiogenesis in the thyroid of Graves' disease (GD) treated with thyroid arterial embolization through analysis of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvessel density (MVD).

Materials And Methods: Forty-two GD patients were treated with thyroid arterial embolization and followed up for 1-68 months after embolization. Before embolization and at 7 days, 3, 6, 12, 36 and 48 months following embolization, TT3, TT4, FT3, FT4, TSH and thyroid stimulating antibody (TSAb) were tested respectively. Thyroid biopsy was performed under the guidance of computed tomography for immunohistochemical staining of VEGF and bFGF, and MVD within the thyroid gland was marked by CD34.

Results: VEGF and bFGF were mostly expressed in the cytoplasm and on the cell membrane. The expression of VEGF was increased (P < 0.05) at < or = 6 months compared with before embolization and decreased (P < 0.05) at > or = 1 year compared with either at < or = 6 months or before embolization. The expression of bFGF was not statistically different at < or = 6 months compared with before embolization but was decreased (P < 0.05) at > or = 1 year compared with either at ?6 months or before embolization. Thyroid MVD marked by CD34 had similar changes to those of the VEGF expression after embolization. There was a positive correlation between VEGF and bFGF (P < 0.05) and between VEGF or bFGF and MVD (P < 0.05). Thyroid hormones mostly returned to normal and TSAb was decreased in longer follow-up.

Conclusion: Thyroid arterial embolization can decrease the expression of VEGF, bFGF and MVD. Consequently, angiogenesis within the GD thyroid will be decreased in the long term after embolization and may serve as the basis for reduced thyroid size and function.

Download full-text PDF

Source

Still can't find the full text of the article?

We can help you send a request to the authors directly.
October 2009
57 Reads
0.971 Impact Factor

Publication Analysis

Top Keywords

vegf bfgf
20
months embolization
16
arterial embolization
16
thyroid arterial
16
embolization
13
bfgf mvd
12
treated thyroid
12
thyroid
12
months compared
8
vegf
8
growth factor
8
embolization decreased
8
angiogenesis thyroid
8
decreased 005
8
005 year
8
compared months
8
graves' disease
8
disease treated
8
expression vegf
8
year compared
8

Similar Publications