Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study.

Eur Child Adolesc Psychiatry 2010 Apr 10;19(4):341-51. Epub 2009 Sep 10.

Child and Adolescent Psychiatric Center Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark.

Only few prospective longitudinal studies have assessed the course of intelligence deficits in early onset schizophrenia (EOS), and these have used different age appropriate versions of Wechsler Intelligence Scales and age appropriate norms. The post-psychotic development of intelligence in EOS has predominantly been characterized as relatively stable in these studies. However, comparisons of IQs from different test versions based on the different norms may not permit unequivocal interpretations. The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8). The same version of a Wechsler Intelligence Scale was administered at both baseline and follow-up assessments, and the same norms were used to derive IQs at baseline and follow-up. Significantly smaller change in mean full scale intelligence quotient (FSIQ) was found in diagnostically stable EOS patients compared with healthy controls during the follow-up period. However, no statistically significant difference in mean FSIQ change was observed between patients with EOS and patients with other non-affective psychoses, although this result must be interpreted with caution due to the small sample sizes. The results suggest abnormally slow acquisition of new intellectual information and skills in EOS patients during the first 5 years after full clinical presentation.

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http://dx.doi.org/10.1007/s00787-009-0053-4DOI Listing
April 2010
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References

(Supplied by CrossRef)

J Alaghband-Rad et al.
J Am Acad Child Adolesc Psychiatry 1995

NC Andreasen et al.
1984

NC Andreasen et al.
1984

NC Andreasen et al.
Arch Gen Psychiatry 1995

T Banaschewski et al.
Eur Child Adolesc Psychiatry 2000

MR Basso et al.
Schizophr Res 1998

JS Bedwell et al.
Am J Psychiatry 1999

GL Canivez et al.
Psychol Assess 1998

KL Cervellione et al.
J Am Acad Child Adolesc Psychiatry 2007

MJ Cuesta et al.
Psychiatry Res 1995

B Fagerlund et al.
2004

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