Experience-dependent structural synaptic plasticity in the mammalian brain.

Authors:
Anthony Holtmaat
Anthony Holtmaat
University of Geneva
Switzerland
Karel Svoboda
Karel Svoboda
Howard Hughes Medical Institute
United States

Nat Rev Neurosci 2009 Sep;10(9):647-58

Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland.

Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal and injured adult brain. Although the overall cell-specific morphology of axons and dendrites, as well as of a subpopulation of small synaptic structures, are remarkably stable, there is increasing evidence that experience-dependent plasticity of specific circuits in the somatosensory and visual cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively. This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions.

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September 2009
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References

(Supplied by CrossRef)
Article in Ann. Rev. Physiol.
Bailey C. H. et al.
Ann. Rev. Physiol. 1993
Article in Nature
Chklovskii D. B. et al.
Nature 2004
Article in J. Cereb. Blood Flow Metab.
Schallert T. et al.
J. Cereb. Blood Flow Metab. 2000
Article in J. Neurosci.
Dancause N. et al.
J. Neurosci. 2005
Article in J. Neurosci.
Brown C. E. et al.
J. Neurosci. 2007
Article in J. Neurosci.
Harris K. M. et al.
J. Neurosci. 1992
Article in Brain Res.
Colonnier M. et al.
Brain Res. 1968
Article in J. Neurosci.
Shepherd G. M. et al.
J. Neurosci. 1998
Article in J. Neurosci.
McGuire B. A. et al.
J. Neurosci. 1984
Article in Annu. Rev. Physiol.
Nimchinsky E. A. et al.
Annu. Rev. Physiol. 2002
Article in J. Neurocytol.
Spacek J. et al.
J. Neurocytol. 1982

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