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Oral misoprostol reduces vaginal bleeding following surgical evacuation for first trimester spontaneous abortion.

Authors:
Mahmoud Shokry Ahmed Y Shahin Mohammed M Fathalla Omar M Shaaban

Int J Gynaecol Obstet 2009 Nov 18;107(2):117-20. Epub 2009 Jul 18.

Department of Obstetrics and Gynecology, Women's Health Centre, Assiut University, Assiut, Egypt.

Objective: To assess the effectiveness and tolerability of misoprostol to reduce the amount and duration of vaginal bleeding following surgical evacuation for first trimester spontaneous abortion.

Methods: A total of 160 patients who underwent surgical evacuation for first trimester spontaneous abortion between 8 and 12 weeks of pregnancy were randomized into 2 groups to receive either 200 microg of oral misoprostol immediately after evacuation followed every 6 hours for 48 hours or no misoprostol. Pain scores, duration and amount of bleeding, and endometrial thickness were assessed over 10 days.

Results: Women who received misoprostol had significantly fewer bleeding days after evacuation (4.11+/-2.69 vs 5.89+/-3.06; P<0.001), fewer patients reported vaginal bleeding lasting 10 days or more (3.8% vs 15.0%; P=0.014), and endometrial thickness 10 days after evacuation was less (6.25+/-2.38 vs 7.23+/-1.94; P=0.05). Pain scores were comparable in both groups (1.54+/-0.65 vs 1.63+/-0.83; P=0.40) after 10 days.

Conclusion: Oral misoprostol is effective in reducing the prevalence and amount of vaginal bleeding after surgical evacuation for first trimester spontaneous abortion.

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http://dx.doi.org/10.1016/j.ijgo.2009.06.008DOI Listing
November 2009

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