Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt.

Breast Cancer Res Treat 2010 Feb 23;120(1):149-60. Epub 2009 Jun 23.

Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, MI, 48109, USA.

Breast cancer incidence is higher in developed countries with higher rates of estrogen receptor positive (ER+) tumors. ER+ tumors are caused by estrogenic exposures although known exposures explain approximately 50% of breast cancer risk. Unknown risk factors causing high breast cancer incidence exist that are estrogenic and development-related. Xenoestrogens are such risk factors but are difficult to study since developed countries lack unexposed populations. Developing countries have urban-rural populations with differential exposure to xenoestrogens. This study assessed urban-rural breast cancer incidence classified by hormone receptor status using data from Gharbiah population-based cancer registry in Egypt from 2001 to 2006. Urban ER+ incidence rate (per 100,000 women) was 2-4 times (IRR = 3.36, 95% CI = 4.84, 2.34) higher than rural incidence rate. ER-incidence rate was 2-3 times (IRR = 1.86, 95% CI = 2.38, 1.45) higher in urban areas than in rural areas. Our findings indicate that urban women may probably have a higher exposure to xenoestrogens.

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http://dx.doi.org/10.1007/s10549-009-0427-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808467PMC
February 2010
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