Search Our Scientific Publications & Authors

eNeuro 2021 Feb 15. Epub 2021 Feb 15.

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461

In the hippocampus, the excitatory synapse between dentate granule cell axons - or mossy fibers (MF) - and CA3 pyramidal cells (MF-CA3) expresses robust forms of short-term plasticity, such as frequency facilitation and post-tetanic potentiation (PTP). These forms of plasticity are due to increases in neurotransmitter release, and can be engaged when dentate granule cells fire in bursts (e.g. Read More

Medicine (Baltimore) 2021 Feb;100(6):e24628

Department of Neurosurgery, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.

Introduction: Central neuropathic pain can result from any type of injury to the central nervous system. Treatment of central neuropathic pain is very challenging. Recently, a novel stimulation paradigm, called burst stimulation, has been presented as an excellent alternative in a group of patients with intractable central neuropathic pain. Read More

Heliyon 2021 Jan 28;7(1):e06132. Epub 2021 Jan 28.

Department of Electrical and Electronic Engineering, College of Technology, University of Buéa, P.O. Box 63, Buéa, Cameroon.

Biological neurons exposed to an external electric field can induce polarization and charge fluctuation. Indeed, the exchange of calcium, sodium and potassium ions across the cell membrane can induce an electric field as a result of a time-varying electromagnetic field set up. This field could further modulate the cell electrical activity by inducing multiple firing modes. Read More

Sci Rep 2021 Feb 5;11(1):3239. Epub 2021 Feb 5.

Department of Neuroscience, Uppsala University, 751 24, Uppsala, Sweden.

Rodent primary somatosensory cortex (S1) is organized in defined layers, where layer IV serves as the main target for thalamocortical projections. Serotoninergic signaling is important for the organization of thalamocortical projections and consequently proper barrel field development in rodents, and the vesicular monoamine transporter 2 (VMAT2) can be detected locally in layer IV S1 cortical neurons in mice as old as P10, but the identity of the Vmat2-expressing neurons is unknown. We here show that Vmat2 mRNA and also Vmat2-Cre recombinase are still expressed in adult mice in a sub-population of the S1 cortical neurons in the barrel field. Read More

J Physiol 2021 Jan 15. Epub 2021 Jan 15.

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Key Points: Mouse chromaffin cells in acute adrenal slices exhibit two distinct spiking patterns, a repetitive mode and a bursting mode. A sodium background conductance operates at rest as demonstrated by the membrane hyperpolarization evoked by a low Na -containing extracellular saline. This sodium background current is insensitive to TTX, is not blocked by Cs ions and displays a linear I-V relationship at potentials close to chromaffin cell resting potential. Read More