Incomplete hippocampal inversion-is there a relation to epilepsy?

Eur Radiol 2009 Oct 14;19(10):2544-50. Epub 2009 May 14.

Department of Radiology, Uppsala University Hospital, 75185, Uppsala, Sweden.

Incomplete hippocampal inversion (IHI) has been described in patients with epilepsy or severe midline malformations but also in nonepileptic subjects without obvious developmental anomalies. We studied the frequency of IHI in different epilepsy syndromes to evaluate their relationship. Three hundred patients were drawn from the regional epilepsy register. Of these, 99 were excluded because of a disease or condition affecting the temporal lobes or incomplete data. Controls were 150 subjects without epilepsy or obvious intracranial developmental anomalies. The coronal MR images were analysed without knowledge of the clinical data. Among epilepsy patients, 30% had IHI (40 left-sided, 4 right-sided, 16 bilateral). Of controls, 18% had IHI (20 left-sided, 8 bilateral). The difference was statistically significant (P < 0.05). Of temporal lobe epilepsy (TLE) patients, 25% had IHI, which was not a significantly higher frequency than in controls (P = 0.34). There was no correlation between EEG and IHI laterality. A total of 44% of Rolandic epilepsy patients and 57% of cryptogenic generalised epilepsy patients had IHI. The IHI frequency was very high in some epileptic syndromes, but not significantly higher in TLE compared to controls. No causality between TLE and IHI could be found. IHI can be a sign of disturbed cerebral development affecting other parts of the brain, maybe leading to epilepsy.

Download full-text PDF

Source
http://link.springer.com/10.1007/s00330-009-1438-y
Publisher Site
http://dx.doi.org/10.1007/s00330-009-1438-yDOI Listing
October 2009
7 Reads

Publication Analysis

Top Keywords

epilepsy patients
12
ihi
10
epilepsy
9
ihi ihi
8
developmental anomalies
8
ihi left-sided
8
incomplete hippocampal
8
patients
6
statistically 005
4
005 temporal
4
difference statistically
4
18% ihi
4
left-sided bilateral
4
bilateral difference
4
temporal lobe
4
lobe epilepsy
4
ihi higher
4
higher frequency
4
25% ihi
4
patients 25%
4

Altmetric Statistics

Similar Publications