J Colloid Interface Sci 2009 Aug 14;336(2):634-41. Epub 2009 Apr 14.
HSG-IMIT-Institute for Micromachining and Information Technology, Wilhelm-Schickard-Strasse 10, D-78052 Villingen-Schwenningen, Germany.
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J Microencapsul 2006 Feb;23(1):91-103
School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
To prepare the sustained release vitamin C carriers, vitamin C was successfully encapsulated in tripolyphosphate (TPP) cross-linked chitosan (TPP-chitosan) microspheres by the spray-drying method at different manufacturing conditions. Manufacturing parameters (inlet temperature, liquid flow rate, chitosan concentration and volume of 1% w/v TPP solution) had a significant influence on the characteristics of thus prepared microspheres. The optimum spray-drying conditions such as inlet temperature, liquid flow rate and compressed air flow rate for the encapsulation of vitamin C in TPP-chitosan microspheres was found to be 170 degrees C, 2 ml min(-1) and 101 min(-1), respectively. Read More
Biomacromolecules 2001 ;2(4):1198-205
Laboratoire Génie de l'Environnement Industriel, Ecole des Mines d'Alès, 6, avenue de Clavières, F-30319 Alès Cedex, France.
A new process is described for the preparation of chitosan gel beads using molybdate as the gelling agent. This new gelation technique leads to a structure different from that produced during alkaline coagulation of a chitosan solution. Instead of a morphology characterized by large open pores, gel beads produced in a molybdate solution, under optimum conditions (pH 6; molybdate concentration, 7 g x L(-1)), have a double layer structure corresponding to a very compact 100-microm thick external layer and an internal structure of small pores. Read More
Biomed Microdevices 2009 Feb;11(1):243-9
The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
This work describes a novel microfluidic method to prepare monodispersed chitosan microspheres by using the solvent extraction method. Our strategy is that a chitosan/acetic acid aqueous solution is emulsified in an organic phase containing the extractant by using the co-flowing shear method in a co-axial microfluidic device. The formed droplets are in situ solidified within a synthesizing channel by the extraction of acetic acid from the chitosan aqueous droplets to the organic solution. Read More
J Periodontal Res 2008 Dec 25;43(6):642-8. Epub 2008 Jun 25.
Institute of Technology Management, Chung Hua University, Hsin Chu, Taiwan.
Background And Objective: The aim of this study was to design a tripolyphosphate-chitosan cross-linked tetracycline-containing (TPP-TC) sponge that slowly releases tetracycline, for future periodontal applications.
Material And Methods: Chitosan sponge was made by freezing and drying 2.5% chitosan solution. Read More