Molecular photoacoustic tomography with colloidal nanobeacons.

Angew Chem Int Ed Engl 2009 ;48(23):4170-3

C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA.

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

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Source
http://doi.wiley.com/10.1002/anie.200805947
Publisher Site
http://dx.doi.org/10.1002/anie.200805947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885454PMC
June 2009
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