J Infect 2009 Jun 31;58(6):469-71. Epub 2009 Mar 31.
J Clin Gastroenterol 2022 Jan 20. Epub 2022 Jan 20.
Departments of Internal Medicine Gastroenterology and Hepatology Mulford Health Sciences Library, The University of Toledo, Toledo, OH Department of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, VA Department of Gastroenterology and Hepatology, The University of Tennessee, TN Center for Advanced Therapeutic Endoscopy (CATE), Centura Health, Denver, CO.
Introduction And Aim: Fecal microbiota transplantation (FMT) is an effective treatment for recurrent/refractory Clostridioides difficile infection (CDI) with a 10% to 20% risk of recurrence after a single FMT. In this meta-analysis, we aimed to evaluate the predictors of FMT failure.Methods: A comprehensive search of MEDLINE, Embase, Cochrane, and Web of Science databases through July 2021 was performed. Read More
Clin Endosc 2022 Jan 20. Epub 2022 Jan 20.
Division of Gastroenterology, Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University, College of Medicine, Incheon, Korea.
Ischemic colitis is an inflammatory condition of the colon that results from insufficient blood supply commonly caused by enterocolitis, vessel occlusion, or shock. In contrast, pseudomembranous colitis is a clinical manifestation of Clostridioides difficile infection (CDI). Ischemic colitis caused by CDI has rarely been reported. Read More
N Engl J Med 2022 01;386(3):220-229
From Yale University School of Medicine, New Haven, and PACT Gastroenterology Center, Hamden - both in Connecticut (P.F.); the University of Calgary and Foothills Medical Centre, Calgary, AB, Canada (T.J.L.); Cleveland Clinic, Cleveland (B.L.); Seres Therapeutics, Cambridge, MA (E.E.L.W., L.D., J.A.B., C.B.F., M.-J.L., K.D.L., J.R.W., H.W., J.G.A., C.W.J.M., J.A.W., B.H.M., M.T., M.R.H., L.M.); Beaumont Hospital, Royal Oak, Royal Oak, and Oakland University William Beaumont School of Medicine, Rochester - both in Michigan (M.S.); Emory University, Atlanta (C.S.K.); the University of California, Davis, Davis (S.H.C.); the University at Buffalo and Veterans Affairs Western New York Healthcare System - both in Buffalo (C.S.B.); and Capital Digestive Care, Washington, DC (L.Y.K.).
Background: Current therapies for recurrent infection do not address the disrupted microbiome, which supports spore germination into toxin-producing bacteria. SER-109 is an investigational microbiome therapeutic composed of purified Firmicutes spores for the treatment of recurrent infection.Methods: We conducted a phase 3, double-blind, randomized, placebo-controlled trial in which patients who had had three or more episodes of infection (inclusive of the qualifying acute episode) received SER-109 or placebo (four capsules daily for 3 days) after standard-of-care antibiotic treatment. Read More
J Microbiol Immunol Infect 2022 Jan 4. Epub 2022 Jan 4.
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Background: Several studies have highlighted the incidence of Clostridioides difficile infections (CDIs) in Taiwan and certain ribotypes have been related to severe clinical diseases. A study was conducted to investigate the polymerase chain reaction (PCR) ribotypes and genetic relatedness of clinical C. difficile strains collected from January 2009 to December 2015 at a hospital in northeastern Taiwan. Read More
Antonie Van Leeuwenhoek 2022 Jan 18. Epub 2022 Jan 18.
Department of Medical Microbiology, Section Experimental Bacteriology, Leiden University Medical Center, Leiden, The Netherlands.
Fluorescence microscopy is a valuable tool to study a broad variety of bacterial cell components and dynamics thereof. For Clostridioides difficile, the fluorescent proteins CFP, mCherry and phiLOV2.1, and the self-labelling tags SNAP and HaloTag, hereafter collectively referred as fluorescent systems, have been described to explore different cellular pathways. Read More