Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Growth failure in children and adolescents with Crohn's disease.

Authors:
Katja Tietjen Rolf Behrens Edda Weimann

Turk J Gastroenterol 2009 Mar;20(1):13-9

Kinder- und Jugendklinik der Friedrich-Alexander-Universität Erlangen Klinik für Kinderheilkunde und Jugendmedizin am Sankt Bernward Krankenhaus Hildesheim, Nürnberg, Germany.

Background/aims: A clinical analysis in children, adolescents and young adults with Crohn's disease was performed to investigate if growth failure is caused by an impaired growth hormone secretion in these patients.

Methods: 40 patients with Crohn's disease (26 male, 14 female) with an average age of 16,7 years (median: 17,0 years, range: 4-29) were included in the study. The observation period varied from 8 months to 16,7 years, patient's age ranged from 4 years up to 29 years. To examine growth hormone excretion, urinary growth hormone was measured using an in vitro immunoradiometric assay in three morning urine samples. Renal function was obtained by analysing creatinine and alpha-1-microglobulin in the same samples. Observation period, chronological age, height, growth rate, pubertal stage, localisation, pediatric Crohn disease activity index and corticosteroid treatment as well as IGF-1 levels were determined. We found normal urinary growth hormone levels in Crohn's disease concluding that growth failure in patients with Crohn's disease is not caused by growth hormone deficiency. Evenly corticosteroid therapy did not appear to be the most responsible factor for growth failure in Crohn's disease.

Conclusions: Disease activity indicated by a high pediatric Crohn disease activity index score had an important impact on impaired growth in children and adolescents with Crohn's disease.

Download full-text PDF

 Source
March 2009

Publication Analysis

Top Keywords

crohn's disease
24
growth hormone
20
growth failure
16
children adolescents
12
disease activity
12
growth
11
disease
9
impaired growth
8
pediatric crohn
8
observation period
8
urinary growth
8
crohn disease
8
167 years
8
adolescents crohn's
8
patients crohn's
8
crohn's
7
hormone
5
years
5
excretion urinary
4
measured vitro
4

Similar Publications

New Findings of Immunodysregulation, Polyendocrinopathy, and Enteropathy X-linked Syndrome (IPEX); Granulomas in Lung and Duodenum.

Authors:
Demet Teker Duztas Lina Al-Shadfan Hakan Ozturk Hakan Yazan Erkan Cakir Nurcan Unver Ozgur Ekinci Buket Dalgic Meino Rohlfs Tim Jeske Christoph Klein Daniel Kotlarz Odul Egritas Gurkan

Pediatr Dev Pathol 2021 Mar 8:1093526621998868. Epub 2021 Mar 8.

Department of Pediatric Gastroenterology and Hepatology, Gazi University, Ankara, Turkey.

Immune dysregulation, polyendocrinopathy and enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by loss-of-function mutations in the gene forkhead box protein 3 (FOXP3). IPEX patients frequently show chronic diarrhea (enteropathy) associated with villous atrophies in the small intestine. Our case is different from this classical information in the literature, since he presented with neonatal onset inflammatory bowel disease within the first months of life accompanied by deep ulcers throughout colonic mucosa. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: A south Asian region-specific systematic review and meta-analysis.

Authors:
Anuraag Jena Daya Krishna Jha Praveen Kumar-M Kripa Shanker Kasudhan Ankit Kumar Dhruv Sarwal Shubhra Mishra Anupam Kumar Singh Prateek Bhatia Amol Patil Vishal Sharma

Expert Rev Clin Pharmacol 2021 Mar 6. Epub 2021 Mar 6.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, GMCH-32, Chandigarh, India.

: Prevalence and impact of thiopurine S-methyltransferase () and Nudix hydrolase () minor allele frequencies in South Asian population is unclear.: We searched PubMed and Embase with keywords- and combined with South Asian countries. We included studies reporting frequency of and polymorphisms. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β-glucan exposure.

Authors:
Kelong Ma Mengli Chen Juanjuan Liu Yuzhu Ge Tianming Wang Daqiang Wu Guiming Yan Changzhong Wang Jing Shao

J Leukoc Biol 2021 Mar 8. Epub 2021 Mar 8.

Laboratory of Infection and Immunity, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Xinzhan District, Hefei, Anhui, China.

Inflammatory bowel disease (IBD) including Crohn's disease and ulcerative colitis is a chronic intestinal disease most likely associated with gut dysbiosis. Candida related mycobiota has been demonstrated to play a role in IBD progression. Traditional Chinese herbal medicines (TCHMs) with antifungal activity have a potential in prevention and treatment of fungi-related IBD. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Newly Diagnosed Patients with Inflammatory Bowel Disease: The Relationship Between Perceived Psychological Support, Health-Related Quality of Life, and Disease Activity.

Authors:
Kristy Engel Maher Homsi Rie Suzuki Karla Helvie Jeremy Adler Caitlyn Plonka Ellen Zimmermann

Health Equity 2021 2;5(1):42-48. Epub 2021 Feb 2.

Division of Gastroenterology, Department of Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

Newly diagnosed patients with inflammatory bowel disease (IBD) encounter many physical, mental, and social uncertainties. In other chronic diseases, patients having access to disease-specific information and psychological support adhere better to medical regimens. Currently, there is a paucity of data on how newly diagnosed patients with IBD interact with their medical providers. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Intestinal Tuberculosis: A Diagnostic Challenge.

Authors:
Hansang Park Tikal Kansara Ana M Victoria Noella Boma Jungrak Hong

Cureus 2021 Feb 1;13(2):e13058. Epub 2021 Feb 1.

Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.

Diagnosing intestinal tuberculosis (TB) with uncommon clinical manifestations is often challenging. Here, we report a case of an alcoholic patient who presented with vague symptoms and was later diagnosed with intestinal TB. This patient experienced multiorgan failure causing hemodynamic instability requiring ionotropic support; acute hypoxic respiratory failure managed with non-invasive positive pressure ventilation, hepatic failure, transudative peritoneal effusion, and transudative pleural effusion. Read More

View Article and Full-Text PDF
February 2021
Similar Publications