Pediatr Infect Dis J 2009 May;28(5):435-8
Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.
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Acta Paediatr 2009 May 9;98(5):873-8. Epub 2009 Jan 9.
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Aim: To identify clinical and biochemical factors associated with sclerema in infants with diarrhoeal illness, and their outcome.
Methods: In this case-control study, we enrolled 30 infants with clinical sepsis with sclerema (cases) and another 60, age- and sex-matched infants with clinical sepsis but without sclerema (controls) from among those admitted to the special care unit (SCU) and longer stay unit (LSU) of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) for their diarrhoeal illness from May 2005 through April 2006. Sclerema as the dependant variable while hypoxia, hypothermia, C-reactive protein (CRP) level, serum total protein and prealbumin level were the major independent variables compared in the analysis. Read More
JOGN Nurs 1983 Nov-Dec;12(6):391-4
High-risk infants are particularly prone to sepsis which can be accompanied by sclerema neonatorum. This condition is manifested by skin hardening. Causation of hardening of a sick infant's skin must be identified for appropriate treatment to be implemented. Read More
Neonatology 2008 7;94(2):123-31. Epub 2008 Mar 7.
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md. 21205, USA.
Background: Few studies from developing countries have examined sensitivity, specificity, positive and negative predictive values of routine surface cultures.
Objectives: The purpose of the study was to determine sensitivity, specificity, and positive predictive value (PPV) of skin cultures among preterm neonates admitted to Dhaka Shishu Hospital, Bangladesh.
Methods: The study was nested within a prospective, randomized, controlled trial of emollient treatment in Dhaka Shishu Hospital, Bangladesh. Read More
Indian Pediatr 1997 Jan;34(1):20-5
Department of Pediatrics, Maulana Azad Medical College, New Delhi.
Objective: To study the effect of exchange transfusion (ET) on the levels of immunoglobulins (Ig) and C3 in neonatal sepsis with sclerema.
Design: Randomized controlled trial in a referral neonatal unit of a teaching hospital.
Subjects: Consecutive culture positive septic neonates with sclerema were enrolled and were randomized to undergo ET (study group, n = 20) or no ET (controls, n = 20). Read More