Anticonvulsant and neurotoxicity evaluation of new bromophthalimidobutyryl amide derivatives.

Authors:
Dr. Mehnaz Kamal, PhD
Dr. Mehnaz Kamal, PhD
College of Pharmacy, Prince Sattam Bin Abdulaziz University
Assistant Professor
Medicinal chemistry
Al Kharj, Riyadh | Saudi Arabia

Acta Pol Pharm 2009 Jan-Feb;66(1):65-8

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

A series of 4-(5-bromo-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-butyryl N-(substituted phenyl) amides (3a-I) were synthesized and evaluated for their anticonvulsant activity in MES test according to the protocols of Antiepileptic Drug Development (ADD) programme of National Institutes of Health (NIH, Bethesda, USA).The most active compounds of the series were 3a, 3c, 3d, 3f, 3g, 3i and 3k at the dose of 30 mg/kg (i.p.) 0.5 h and 4 h after administration. In neurotoxic screen (NT), 3d, 3i and 3k were less toxic when compared with the other compounds.

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March 2009
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