BJU Int 2009 May 14;103(9):1275-83. Epub 2009 Jan 14.
Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.
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Anticancer Res 2007 Mar-Apr;27(2):873-81
University Hospital Zurich, Department of Internal Medicine, Institute for Complementary Medicine, Rämistrasse 100, 8091 Zurich, Switzerland.
Background: Phytotherapy is a third approach for treating lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). The lipido-sterolic extract of the fruit of Serenoa repens is one of the more widely used phytotherapeutic agents in this regard.
Materials And Methods: The effect of an ethanolic extract of S. Read More
J Cell Physiol 2009 Apr;219(1):69-76
Department Experimental Medicine, Sapienza University of Rome, Rome, Italy.
The molecular mechanism by which the lipido-sterolic extract of Serenoa repens (LSESr, Permixon) affects prostate cells remains to be fully elucidated. In androgen-independent PC3 prostate cancer cells, the LSESr-induced effects on proliferation and apoptosis were evaluated by counting cells and using a FACScan cytofluorimeter. PC3 cells were stained with JC-1 dye to detect mitochondrial membrane potential. Read More
Anticancer Res 2009 Jun;29(6):2195-204
Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan.
Background: Ion channel modulators have been previously associated with cell proliferation and cell death in human cancer cell lines.
Materials And Methods: The effects of riluzole, an ion channel modulator, on cell proliferation, apoptosis and the apoptotic pathway in the LNCaP and C4-2 prostate cancer cell lines were investigated.
Results: Riluzole inhibited DNA synthesis and increased apoptotic cells in both cell lines. Read More
Arch Pharm Res 2006 Dec;29(12):1140-6
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Ceramide analogs are potential chemotherapeutic agents. We report that a ceramide analog induces apoptosis in human prostate cancer cells. The ceramide analog induced cell death through an apoptotic mechanism, which was demonstrated by DNA fragmentation, the cleavage of poly ADP ribose polymerase (PARP), and a loss of membrane asymmetry. Read More