Metastasis is the main cause of death in patients with malignancy. We found that Trihydrophobin 1 (TH1) can inhibit PAK1 kinase activity and MAPK pathway, And, TH1 localized to feet of cancer cells (focal adhesions and filopodia in the leading edge of cells), where TH1 reduced cell migration through affecting actin and adhesion dynamics.
There are still many unresolved issues regarding how the signal of cell migration is regulated, when and where important molecular complexes form and disperse. We provided direct evidence that TH1 is a negative regulator of cancer growth and invasion.
It is one of my very interesting studies 10 years ago. I hope this article can inspire you besides providing insight into cancer. Dr. Chunming Cheng, PhD
J Biol Chem 2009 Mar 9;284(13):8786-96. Epub 2009 Jan 9.
Gene Research Center, Shanghai Medical College, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
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