Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer?

Biosci Hypotheses 2008 ;1(4):195-199

School of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA.

An increased incidence of thyroid cancer has been reported in many parts of the world including the United States during the past several decades. Recently emerging evidence has demonstrated that polyhalogenated aromatic hydrocarbons (PHAHs), particularly polybrominated diphenyl ethers (PBDEs), alter thyroid hormone homeostasis and cause thyroid dysfunction. However, few studies have been conducted to test whether exposure to PBDEs and other PHAHs increases the risk of thyroid cancer. Here, we hypothesize that elevated exposure to PHAHs, particularly PBDEs, increases the risk of thyroid cancer and may explain part of the increase in incidence of thyroid cancer during the past several decades. In addition, genetic and epigenetic variations in metabolic pathway genes may alter the expression and function of metabolic enzymes which are involved in the metabolism of endogenous thyroid hormones and the detoxification of PBDEs and other PHAHs. Such variation may result in different individual susceptibilities to PBDEs and other PHAHs and the subsequent development of thyroid cancer. The investigation of this hypothesis will lead to an improved understanding of the role of PBDEs and other PHAHs in thyroid tumorigenesis and may provide a real means to prevent this deadly disease.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bihy.2008.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612591PMC
January 2008
6 Reads

Publication Analysis

Top Keywords

thyroid cancer
20
pbdes phahs
16
risk thyroid
12
thyroid
10
diphenyl ethers
8
increases risk
8
polybrominated diphenyl
8
incidence thyroid
8
ethers pbdes
8
pbdes
7
phahs
6
cancer
5
pbdes increases
4
phahs pbdes
4
cancer explain
4
investigation hypothesis
4
decades addition
4
addition genetic
4
hypothesis will
4
cancer decades
4

Similar Publications