Spinal epidural granulocytic sarcoma in non-leukemic patient.

Authors:
Prof dr Mirjana Gotic, MD, PhD
Prof dr Mirjana Gotic, MD, PhD
Medical Faculty, University of Belgrade, Clinical Centre of Serbia, Belgrade
Haed of the Polyclynic/Diagnostic Department, Clinic for Hematology CCS
Internal Medicine, Hematology
Belgrade | Yugoslavia

Int J Hematol 2009 Jan 26;89(1):95-97. Epub 2008 Dec 26.

Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.

A previously healthy 24-year-old male presented with a 3-month history of progressive backache and weakness in both legs. Magnetic resonance imaging of the spine showed a large soft tissue mass infiltrating paraspinal musculature of lumbosacral area, sacral laminas, last lumbar and all sacral vertebra, protruding into the spinal canal, and with propagation into pelvis. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed resulting in neurological improvement. Histological examination identified granulocytic sarcoma (GS). Bone marrow biopsy showed normal findings. The patient underwent adjuvant chemotherapy and radiotherapy, resulting in the elimination of residual lesion, followed by autologous transplant. Immediate diagnosis and adequate systematic treatment are essential to achieve optimal results in patients with isolated GS. The patient is alive and free of the disease 14 months from the diagnosis.

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http://link.springer.com/10.1007/s12185-008-0227-8
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http://dx.doi.org/10.1007/s12185-008-0227-8DOI Listing
January 2009
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