Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.

Authors:
Jorge Triana
Jorge Triana
University of Las Palmas de Gran Canaria
Spain
Francisco Leon
Francisco Leon
National Institutes of Health
United States
Ignacio Brouard
Ignacio Brouard
University of Pennsylvania
United States
Fernando Torres
Fernando Torres
University of Texas Southwestern Medical Center
United States
Jose Quintana
Jose Quintana
Hospital Galdakao-Usansolo (Osakidetza)-Red de Investigación en Servicios de Salud en Enfermedades Crónicas
Spain
Francisco Estevez
Francisco Estevez
Juan Canalejo Hospital
Spain

J Nat Prod 2008 Dec;71(12):2015-20

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).

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December 2008
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