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J Infect Dis 2021 Mar 1. Epub 2021 Mar 1.

Laboratorio de Inmunobiología y Genética, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

The differentiation of influenza and COVID-19 could constitute a diagnostic challenge during the ongoing winter due to their clinical similitude. Thus, novel biomarkers that enable distinguishing both diseases are required. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Read More

Diabetes Metab Syndr 2021 Feb 23;15(2):487-491. Epub 2021 Feb 23.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.

Background And Aims: Diabetes mellitus (DM) is a chronic metabolic disease associated with long-term multisystem complications, among which nonhealing diabetic foot ulcers (DFUs) are recognized as major cause of morbidity and mortality. Treating DFUs with surgical procedures such as synthetic or biological skin grafts or skin substitutes has several limitations, where none of the currently available skin substitutes is ideal.

Methods: OVID/Medline and PubMed databases were searched using the Medical Subject Heading (MeSH) or Title/Abstract words ("diabetic foot ulcers", "skin substitutes", and "nanofibers"), to identify published research studies on DFUs and nanofibers. Read More

Plant Physiol Biochem 2021 Feb 25;162:36-47. Epub 2021 Feb 25.

Plant Physiology and Biochemistry Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, India. Electronic address:

Unfavorable environmental conditions are the critical inimical to the sustainable agriculture. Among various novel strategies designed to protect plants from abiotic stress threats, use of mineral elements as 'stress mitigators' has emerged as the most crucial and interesting aspect. Silicon (Si) is a quasi-essential nutrient that mediates plant growth and development and interacts with plant growth regulators (PGRs) and signaling molecules to combat abiotic stress induced adversities in plants and increase stress tolerance. Read More

Bioorg Chem 2021 Feb 24;110:104767. Epub 2021 Feb 24.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China. Electronic address:

SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infection treatment. Read More

Bioorg Med Chem 2021 Feb 25;36:116094. Epub 2021 Feb 25.

Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

EGFR inhibitors represent a significant milestone for treatment of non-small cell lung cancer, however, they suffer from the acquired drug resistance. Utilizing osimertinib as the lead compound, this work has explored the structural modifications on the indole and pyrimidine rings of osimertinib to generate novel osimertinib derivatives. The in vitro enzymatic and cellular studies showed that the derivatives possessed high selectivity towards double mutant EGFR and potent antitumor activity. Read More