Apoptotic study in Graves disease treated with thyroid arterial embolization.

Endocr J 2009 14;56(2):201-11. Epub 2008 Nov 14.

Medical Imaging Center, First Affiliated Hospital, Kunming Medical College, Kunmin, Yunnan Province, China.

Objective: To investigate apoptosis in the thyroid of Graves disease (GD) induced by thyroid arterial embolization.

Materials And Methods: Forty one patients with clinically and laboratorily ascertained GD were treated with thyroid arterial embolization and followed up for 3-54 months following embolization. Prior to embolization and at 1, 3, 6, 12 and 36 months following embolization, thyroid autoimmunue antibodies were tested respectively, including thyroid stimulating antibody (TSAb), thyroglobulin antibody (TGAb) and thyroid microsomal antibody (TMAb). Thyroid biopsy was performed under the guidance of computed tomography for immunohistochemistry examination using semi-quantity analysis.

Results: The positive staining of Fas and FasL was mostly in the cytoplasma and cell membrane, the positive expression of Bax was mainly in the cytoplasma, and no positive expression of P53 was detected in the thyroid cells before embolization. After arterial embolziation, the positive cell number and staining degree of these genes were both greater than before embolization.

Conclusion: The treatment method of thyroid arterial embolization can effectively enhance the positive expression of pro-apoptotic genes of Fas, FasL, Bax, Bcl-2 and P53 in GD thyroid, thus promoting apoptosis of GD thyroid and helping restore the thyroid size and function to normal conditions.

Download full-text PDF

Source

Still can't find the full text of the article?

We can help you send a request to the authors directly.
August 2009
4 Reads
2.020 Impact Factor

Publication Analysis

Top Keywords

thyroid arterial
16
thyroid
13
positive expression
12
arterial embolization
12
treated thyroid
8
apoptosis thyroid
8
months embolization
8
fas fasl
8
graves disease
8
embolization
7
positive
5
arterial
5
computed tomography
4
guidance computed
4
effectively enhance
4
enhance positive
4
performed guidance
4
examination semi-quantity
4
method thyroid
4
immunohistochemistry examination
4

Similar Publications