Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition.

Cancer Epidemiol Biomarkers Prev 2008 Nov;17(11):3108-15

IARC, 150, cours Albert Thomas, Lyon, 69372 Lyon Cedex 08, France.

Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon.

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-08-0495DOI Listing
November 2008
82 Reads

Publication Analysis

Top Keywords

colorectal cancer
28
cancer risk
16
cancer
13
10% increase
12
increasing hba1c
8
statistically increase
8
increase hba1c
8
increase colorectal
8
european prospective
8
cancer nutrition
8
prospective investigation
8
hba1c percentages
8
glycosylated hemoglobin
8
investigation cancer
8
colorectal
7
increase
6
risk
6
hba1c
5
percentages statistically
4
statistically associated
4

Similar Publications