Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.

Authors:
Federico Piscione
Federico Piscione
University of Salerno
Fisciano | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Gennaro Galasso
Gennaro Galasso
Federico II University
Italy
Ersilia Cipolletta
Ersilia Cipolletta
Department of Clinical Medicine
Italy
Maria Assunta Rao
Maria Assunta Rao
Department of Clinical Medicine
Italy
Gregorio Brevetti
Gregorio Brevetti
University of Naples Federico II
Italy
Raffaele Piccolo
Raffaele Piccolo
Bern University Hospital
Bern | Switzerland
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy

J Am Coll Cardiol 2008 Oct;52(17):1381-8

Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy.

Objectives: This study investigated the relationship between beta(2)-adrenergic receptor (B2AR) Ile164 polymorphism and coronary artery disease (CAD).

Background: B2ARs are crucial to the regulation of vascular tone, and neoangiogenesis is impaired in the presence of isoleucine at position 164 (Ile164) B2AR gene polymorphism. No data deal with the role of the variants at position 164 of the B2AR gene in the setting of CAD.

Methods: The study population consisted of 330 patients undergoing percutaneous coronary intervention (PCI).

Results: The Ile164 polymorphism frequency was higher in CAD (12.1% vs. 3%, p = 0.008) with respect to the control population. We divided our population into 2 groups: group 1 (290 patients, threonine/threonine genotype at position 164 [164Thr/Thr]) and group 2 (40 patients, threonine/isoleucine genotype at position 164 [164Thr/Ile]). Patients of group 2 presented an earlier onset of CAD (56.7 +/- 7.8 vs. 59.5 +/- 10, p = 0.04) and a higher incidence of multivessel disease (25.4% vs. 41%, p = 0.044). At follow-up, group 2 showed a higher incidence of new acute myocardial infarction (17.5% vs. 4.5%, p = 0.001), new PCI (37.5% vs. 13.1%, p < 0.0001), and cardiac death (10% vs. 3.1%, p = 0.036). Cox regression analysis identified Ile164 as an independent predictor of cardiac death (odds ratio [OR]: 3.731, 95% confidence interval [CI]: 1.004 to 13.867, p = 0.049) and an overall major adverse cardiac event (OR: 4.100, 95% CI: 1.945 to 8.640, p = 0.0001). A replication study was done on a population of 150 patients with peripheral artery disease. The presence of the Ile164 allele was associated with a higher incidence of acute myocardial infarction (54.5% vs. 25.2%, p = 0.035) or combined events (acute myocardial infarction, PCI, or coronary artery bypass graft) (63.6% vs. 30.9%, p = 0.027).

Conclusions: Our study suggests that the B2AR Ile164 mutant is associated with a more aggressive CAD and adversely affects prognosis in patients undergoing PCI.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2008.07.034DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
October 2008
9 Reads
10 Citations
16.503 Impact Factor

Publication Analysis

Top Keywords

position 164
16
myocardial infarction
12
acute myocardial
12
coronary artery
12
higher incidence
12
artery disease
12
ile164 polymorphism
12
incidence acute
8
b2ar ile164
8
patients undergoing
8
beta2-adrenergic receptor
8
b2ar gene
8
study population
8
genotype position
8
cardiac death
8
patients
6
ile164
6
0008 respect
4
adverse cardiac
4
164 [164thr/ile]
4

Similar Publications