Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity.

J Autism Dev Disord 2009 Mar 28;39(3):395-404. Epub 2008 Aug 28.

School of Social and Family Dynamics, Arizona State University, Box 873701, Tempe, AZ 85287-3701, USA.

This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.

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http://dx.doi.org/10.1007/s10803-008-0636-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374624PMC
March 2009
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