The Trichoplax genome and the nature of placozoans.

Nature 2008 Aug;454(7207):955-60

Center for Integrative Genomics and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

As arguably the simplest free-living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the approximately 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole-genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome shows conserved gene content, gene structure and synteny in relation to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signalling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/or as yet unobserved life history stages.

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature07191DOI Listing
August 2008
28 Reads

Publication Analysis

Top Keywords

trichoplax genome
8
relation human
4
human complex
4
synteny relation
4
structure synteny
4
gene structure
4
complex eumetazoan
4
genomes despite
4
cellular organismal
4
organismal simplicity
4
apparent cellular
4
despite apparent
4
content gene
4
eumetazoan genomes
4
genome conserved
4
includes cnidarians
4
cnidarians bilaterians
4
clade includes
4
'eumetazoan' clade
4
belong 'eumetazoan'
4

Similar Publications