Fluorous Mixture Synthesis (FMS) of Enantiomers, Diastereomers, and Compound Libraries.

Authors:
Mr. Wei Zhang, PhD
Mr. Wei Zhang, PhD
University of Minnesota Twin Cities
Minneapolis, Minnesota | United States

ARKIVOC 2004 May;i:101-109

Fluorous Technologies, Inc. University of Pittsburgh Applied Research Center, 970 William Pitt Way Pittsburgh, PA 15238, USA E-Mail:

Fluorous mixture synthesis (FMS) is a newly developed highly-efficient solution-phase technology. A set of substrates attached to homologous fluorous tags is mixed and taken through a sequence of organic reactions. The final mixtures are demixed by fluorous HPLC and detagged to give individually pure final products. Applications of FMS for the preparation of 2 enantiomers of pyridovericin, 16 diastereomers of murisolin, and a 560-member mappicine library are highlighted in this article.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387003PMC
May 2004

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