Food Chem Toxicol 2008 Jul 1;46(7):2415-21. Epub 2008 Apr 1.
University Medical Center Freiburg, Institute of Environmental Medicine and Hospital Hygiene, Breisacher Strasse 115b, 79106 Freiburg, Germany.
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Toxicol In Vitro 2006 Dec 20;20(8):1427-34. Epub 2006 Jul 20.
Institute of Indoor and Environmental Toxicology, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany.
Naturally occurring compounds have protective effects towards mutagens and carcinogens. The leaf extract of Monimiastrum globosum (Bois de Clous), a Mauritian endemic plant from the Myrtaceae family, was studied for its potency to induce DNA damage in human HepG2 hepatoma cells using DNA migration as a biological endpoint in the alkaline single cell gel electrophoresis (SCGE) assay. This was contrasted with the ability to modulate the benzo[a]pyrene (BaP)-dependent DNA damage in human hepatoma cells. Read More
Food Chem Toxicol 2002 Aug;40(8):1077-83
Insitute of Cancer Research, University of Vienna, Borschkegasse 8A, 1090 Vienna, Austria.
The aim of this study was to investigate the chemoprotective effects of Brussels sprouts juice towards benzo[a]pyrene (B(a)P)-induced DNA damage in the single-cell gel electrophoresis (SCGE)/Hep G2 test system. This assay combines the advantages of the SCGE assay with that of the use of human-derived cells possessing inducible phase I and phase II enzymes. Co-treatment of Hep G2 cells with small amounts of Brussels sprouts juice (0. Read More
Arch Toxicol 2003 Aug 11;77(8):477-84. Epub 2003 Jul 11.
Institute of Cancer Research, Borschkegasse 8A, 1090 Vienna, Austria.
The aim of the present study was to investigate the antimutagenic effects of chrysin (CR), a flavonoid compound contained in many fruits, vegetables and honey. Earlier investigations with bacterial indicators showed that CR is one of the most potent antimutagens among the flavonoids. In the present study, we tested the compound in the Salmonella strains TA98 and TA100 in combination with benzo(a)pyrene (B(a)P) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and found pronounced protective activity over a concentration range between 10 and 100 microg/ml. Read More
Teratog Carcinog Mutagen 2003 ;Suppl 1:273-82
Insitute of Cancer Research, University of Vienna, Austria.
The aim of this study was to investigate the chemoprotective effects of mustard sprouts on benzo(a)pyrene [B(a)P]-induced DNA damage in the single cell gel electrophoresis (SCGE)/Hep G2 assay. This model combines the advantages of the SCGE assay with that of human-derived cells that possess inducible phase I and phase II enzymes. Treatment of the cells with small amounts of mustard juice (0. Read More