Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.

Anticancer Drugs 2008 Apr;19(4):431-3

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

A 60-year-old Japanese man presented to our hospital with a painful left hip. Computed tomography showed a tumor in the left kidney and metastases in the left gluteus maximus muscle and lung. The pathological diagnosis of a biopsy specimen obtained from a metastatic lesion in the left gluteus maximus muscle was sarcomatoid renal cell carcinoma. On admission, his general condition was extremely poor. He was confined to bed because of severe left hip pain and confusion, possibly caused by hypercalcemia. This seriously ill patient suffering from advanced sarcomatoid renal cell carcinoma was treated with single-agent gemcitabine, resulting in symptom relief and a dramatic improvement in his status; all of the tumors had regressed significantly by the 11th dose of gemcitabine. These findings indicate that single-agent gemcitabine is one of the few chemotherapeutic agents effective for palliation in patients with sarcomatoid renal cell carcinoma, even those with poor performance status.

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00001813-200804000-000
Publisher Site
http://dx.doi.org/10.1097/CAD.0b013e3282f5d336DOI Listing
April 2008
6 Reads

Publication Analysis

Top Keywords

renal cell
16
cell carcinoma
16
sarcomatoid renal
16
single-agent gemcitabine
12
left gluteus
8
maximus muscle
8
left hip
8
gluteus maximus
8
left
5
dose gemcitabine
4
admission general
4
general condition
4
condition extremely
4
poor confined
4
extremely poor
4
carcinoma admission
4
11th dose
4
lesion left
4
pathological diagnosis
4
diagnosis biopsy
4

Similar Publications