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Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management.

Curr Opin Neurol 2021 Feb 24. Epub 2021 Feb 24.

J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States Center for Imaging Sciences and Medical Physics. Department of Medical Imaging, Hematology and Clinical Oncology. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, Faculty of Medicine, University of Geneva, Geneva, Switzerland Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Departments of Epidemiology and Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands Both Maria Clara Zanon Zotin and Lukas Sveikata contributed equally to the manuscript.

Purpose Of Review: We present recent developments in the field of small vessel disease (SVD)-related vascular cognitive impairment, including pathological mechanisms, updated diagnostic criteria, cognitive profile, neuroimaging markers and risk factors. We further address available management and therapeutic strategies.

Recent Findings: Vascular and neurodegenerative pathologies often co-occur and share similar risk factors. Read More

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February 2021

Nursing diagnoses of impaired memory and chronic confusion for older adults: diagnostic content validation.

Rev Bras Enferm 2021 12;74(suppl 2):e20200370. Epub 2021 Feb 12.

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.

Objective: To validate the defining characteristics of the nursing diagnoses, impaired memory and chronic confusion for older adults, by testing diagnostic concept definitions among expert nurses.

Methods: We used a Diagnostic content validation using an online survey of expert clinical nurses.

Results: 195 expert nurses performed the diagnostic validations. Read More

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February 2021

Endocrine Diseases of Newborn: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome "Current Insights Into Disorders of Calcium and Phosphate in the Newborn".

Front Pediatr 2021 5;9:600490. Epub 2021 Feb 5.

Department of Endocrinology and Metabolic Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

The physiology and regulation of bone minerals in the fetus and the newborn is significantly different from children and adults. The bone minerals calcium, phosphate and magnesium are all maintained at higher concentrations to achieve adequate bone accretion. This is an integral component of normal fetal development which facilitates safe neonatal transition to post-natal life. Read More

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February 2021

Revisiting Strategies for Maternal Health Care in the Face of COVID-19 Pandemic.

Authors:
N Shrestha G Dangal

Kathmandu Univ Med J (KUMJ) 2020 COVID-19 SPECIAL ISSUE;18(70):62-67

Department of Obstetrics and Gynaecology, Kathmandu Model Hospital, Kathmandu, Nepal.

Novel coronavirus (SARS-CoV-2) is a new strain of coronavirus causing COVID-19, first identified in Wuhan City, China towards the end of 2019. At present, there is no evidence that pregnant women are more likely to be severely ill, need ICU care, or die from the illness in comparison to non-pregnant adults. Evidences suggest that vertical transmission, might be possible. Read More

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February 2021