Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy.

Authors:

Autoimmunity 2008 Apr;41(3):218-23

School of Clinical Veterinary Science, University of Bristol, Bristol, UK.

Tartrate-resistant acid phosphatase (TRAP), once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread occurrence with functions in both the skeleton and the immune system. TRAP is expressed by osteoclasts, macrophages, dendritic cells and a number of other cell types. It has a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone, cytokine production by macrophages and dendritic cells, macrophage recruitment, dendritic cell maturation and a role in the development of Th1 responses. TRAP is able to degrade skeletal phosphoproteins including osteopontin (OPN), identical to the T-cell cytokine, Eta-1. In this review, we discuss the role of TRAP in bone and immune cells and suggest that TRAP may be implicated in autoimmune disorders regulated by Th1 inflammatory responses as well as certain cancers.

Download full-text PDF

Source
http://dx.doi.org/10.1080/08916930701694667DOI Listing
April 2008

Publication Analysis

Top Keywords

phosphatase trap
8
macrophages dendritic
8
acid phosphatase
8
dendritic cells
8
tartrate-resistant acid
8
trap
6
role trap
4
collagen synthesis
4
development collagen
4
trap bone
4
synthesis degradation
4
discuss role
4
mineralisation bone
4
skeletal development
4
degradation mineralisation
4
bone cytokine
4
bone immune
4
critical role
4
types critical
4
opn identical
4

References

(Supplied by CrossRef)

Minkin C et al.
Calcif Tissue Int 1982

Hayman AR et al.
J Histochem Cytochem 2000

Perez-Amodio S et al.
Calcif Tissue Int 2006

Efstratiadis T et al.
Enzyme 1985

Yamamoto T et al.
J Electron Microsc (Tokyo) 1998

Perez-Amodio S et al.
Bone 2005

Hayman AR et al.
J Anat 2000

Hayman AR et al.
Biochem J 1991

Similar Publications