The genome of the model beetle and pest Tribolium castaneum.

Authors:

Nature 2008 Apr 23;452(7190):949-55. Epub 2008 Mar 23.

Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature06784DOI Listing
April 2008
88 Reads

Publication Analysis

Top Keywords

tribolium castaneum
8
content function
4
gene content
4
reflected gene
4
drosophila fact
4
fact reflected
4
function example
4
example tribolium
4
genes involved
4
involved cell-cell
4
ancestral genes
4
retained ancestral
4
tribolium retained
4
insects drosophila
4
tribolium representative
4
expansions odorant
4
odorant gustatory
4
large expansions
4
environment large
4
chemical environment
4

References

(Supplied by CrossRef)

T Hunt et al.
Science 2007

A Sokoloff et al.
1977

MD Lorenzen et al.
Insect Mol. Biol. 2007

G Bucher et al.
Curr. Biol. 2002

Y Tomoyasu et al.
Dev. Genes Evol. 2004

D Tautz et al.
1994

D Tautz et al.
Dev. Cell 2004

MD Lorenzen et al.
Genetics 2005

JP Demuth et al.
Mol. Ecol. Notes 2007

SJ Brown et al.
Insect Biochem. 1990

Similar Publications