An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers.

Psychopharmacology (Berl) 2008 May 19;198(1):127-39. Epub 2008 Mar 19.

Brain Sciences Institute, Swinburne University, Melbourne, VIC, 3122, Australia.

Rationale: Species of Salvia (sage) have a long-standing reputation in European medical herbalism, including for memory enhancement. In recent controlled trials, administration of sage extracts with established cholinergic properties improved cognitive function in young adults.

Objectives: This randomised, placebo-controlled, double-blind, balanced, five-period crossover study investigated the acute effects on cognitive performance of a standardised extract of Salvia officinalis in older adults.

Materials And Methods: Twenty volunteers (>65 years of age, mean = 72.95) received four active doses of extract (167, 333, 666 and 1332 mg) and a placebo with a 7-day wash-out period between visits. Assessment involved completion of the Cognitive Drug Research computerised assessment battery. On study days, treatments were administered immediately following a baseline assessment with further assessment at 1, 2.5, 4 and 6 h post treatment.

Results: Compared with the placebo condition (which exhibited the characteristic performance decline over the day), the 333-mg dose was associated with significant enhancement of secondary memory performance at all testing times. The same measure benefited to a lesser extent from other doses. There also were significant improvements to accuracy of attention following the 333-mg dose. In vitro analysis confirmed cholinesterase inhibiting properties for the extract.

Conclusions: The overall pattern of results is consistent with a dose-related benefit to processes involved in efficient stimulus processing and/or memory consolidation rather than retrieval or working memory efficiency. These findings extend those of the memory-enhancing effects of Salvia extracts in younger populations and warrant further investigation in larger series, in other populations and with different dosing regimes.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-008-1101-3DOI Listing
May 2008
4189 Reads

Publication Analysis

Top Keywords

salvia sage
8
333-mg dose
8
extract salvia
8
memory
5
assessment post
4
treatmentresults compared
4
compared placebo
4
assessment assessment
4
post treatmentresults
4
baseline assessment
4
study days
4
days treatments
4
treatments administered
4
administered baseline
4
placebo condition
4
characteristic performance
4
associated enhancement
4
enhancement secondary
4
secondary memory
4
memory performance
4

References

(Supplied by CrossRef)

JP Aggleton et al.
Behav Brain Sci 1999

S Akhondzadeh et al.
J Clin Pharm Ther 2003

T Bartram et al.
1998

GL Ellman et al.
Biochem Pharmacol 1961

JM Gardiner et al.
2000

K Herholz et al.
NeuroReport 2005

MJR Howes et al.
Phytother Res 2003

M Imanshahidi et al.
Phytother Res 2006

DO Kennedy et al.
Curr Pharm Des 2005

DO Kennedy et al.
Nutr Neurosci 2001

DO Kennedy et al.
Nutr Neurosci 2001

Similar Publications