Gender related differences in patients presenting with acute heart failure. Results from EuroHeart Failure Survey II.

Authors:
Markku S Nieminen
Markku S Nieminen
Heart and Lung Center
Bend | United States
Veli-Pekka Harjola
Veli-Pekka Harjola
Helsinki University Central Hospital
Finland
Matthias Hochadel
Matthias Hochadel
Institut für Herzinfarktforschung Ludwigshafen an der Universität Heidelberg
Germany
Helmut Drexler
Helmut Drexler
Hannover Medical School
Hannover | Germany
Michel Komajda
Michel Komajda
European Society of Cardiology
Dirk Brutsaert
Dirk Brutsaert
Middelheim Hospital
Kenneth Dickstein
Kenneth Dickstein
University of Bergen
Bergen | Norway
Piotr Ponikowski
Piotr Ponikowski
Medical University
Charleston | United States

Eur J Heart Fail 2008 Feb;10(2):140-8

Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland.

Aims: This analysis evaluates the gender differences in patients hospitalised for acute heart failure (AHF) in the EuroHeart Failure Survey II (EHFS).

Results: Of the 3580 patients included in EHFS II, 1384 (39%) were women, mean age 73 years. 2196 (61%) were men, mean age 68 years. Women more frequently had new-onset AHF, hypertension and valvular disease and less frequently coronary heart disease or dilated cardiomyopathy compared with men. Smoking, chronic obstructive pulmonary disease, peripheral arterial disease and renal failure were less common, but diabetes and anaemia significantly more frequent in women. Atrial fibrillation and preserved left ventricular function were more common in women. Men were more often non-compliant with medication. After adjustment for indications and age, there were no significant gender differences in prescription of HF medication. All-cause readmission rate during the one-year follow-up was lower in women. However, the proportion of HF hospitalisation and one-year mortality after discharge (20%) were similar in both genders.

Conclusion: Women frequently present with new-onset AHF. A significant gender difference exists in aetiology, ventricular function and co-morbidities. Women's use of HF medication has improved. These findings emphasize the importance of individualised management and need for more comprehensive recruitment of women in clinical trials.

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Source
http://dx.doi.org/10.1016/j.ejheart.2007.12.012DOI Listing
February 2008
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