Clozapine use in children and adolescents.

Expert Opin Pharmacother 2008 Feb;9(3):459-65

Montreal Neurological Institute, Canada.

Background: Although the role of clozapine is well established for treatment-resistant schizophrenia, it is rarely used in pediatric populations, mainly due to its potentially serious adverse effects.

Objective: To summarize practical aspects of use of clozapine in treating children with schizophrenia and management of associated adverse effects.

Methods: Available studies in the literature using clozapine in the pediatric population are summarized and the NIMH experience in treating refractory childhood-onset schizophrenia cases with clozapine is discussed.

Conclusion: Despite a higher incidence of adverse effects in children, clozapine appears to be a uniquely beneficial second-line agent for treating children with refractory schizophrenia.

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http://dx.doi.org/10.1517/14656566.9.3.459DOI Listing
February 2008
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