A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells.

Authors:
Francisco Leon
Francisco Leon
National Institutes of Health
United States
Ignacio Brouard
Ignacio Brouard
University of Pennsylvania
United States
Fernando Torres
Fernando Torres
University of Texas Southwestern Medical Center
United States
Jose Quintana
Jose Quintana
Hospital Galdakao-Usansolo (Osakidetza)-Red de Investigación en Servicios de Salud en Enfermedades Crónicas
Spain
Augusto Rivera
Augusto Rivera
Ciudad Universitaria
Colombia
Francisco Estevez
Francisco Estevez
Juan Canalejo Hospital
Spain
Jaime Bermejo
Jaime Bermejo
Università di Ferrara
Italy

Chem Biodivers 2008 Jan;5(1):120-5

Instituto de Productos Naturales y Agrobiología, CSIC, Instituto Universitario de Bio-Orgánica Antonio González, Av. Astrofísico F. Sánchez 3, E-38206 La Laguna, Tenerife.

A new phytosphingosine-type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. F. Gray, along with ten known compounds: ergosta-4,6,8(14),22-tetraen-3-one, ergosterol, ergosterol peroxide, suillin, (E)-3,4,5-trimethoxycinnamic alcohol, 5 alpha,6 alpha-epoxyergosta-8,22-diene-3beta,7 beta-diol, (R)-1-palmitoylglycerol, ergosta-7,9(11),22-triene-3beta,5 alpha,6 beta-triol, cerevisterol, and 4-hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass-spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK-MEL-1. Both drugs showed IC(50) values of ca. 10 microM after 72 h of exposure.

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January 2008
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