An independent dose calculation algorithm for MLC-based radiotherapy including the spatial dependence of MLC transmission.

Phys Med Biol 2008 Feb 7;53(3):557-73. Epub 2008 Jan 7.

Department of Radiation Oncology, Mannheim Medical Centre, University of Heidelberg, Mannheim, Germany.

An analytical dose calculation algorithm was developed and commissioned to calculate dose delivered with both static and dynamic multileaf collimator (MLC) in a homogenous phantom. The algorithm is general; however, it was designed specifically to accurately model dose for large and complex IMRT fields. For such fields the delivered dose may have a considerable contribution from MLC transmission, which is dependent upon spatial considerations. Specifically, the algorithm models different MLC effects, such as interleaf transmission, the tongue-and-groove effect, rounded leaf ends, MLC scatter, beam hardening and divergence of the beam, which results in a gradual MLC transmission fall-off with increasing off-axis distance. The calculated dose distributions were compared to measured dose using different methods (film, ionization chamber array, single ionization chamber), and the differences among the treatment planning system, the measurements and the developed algorithm were analysed for static MLC and dynamic IMRT fields. It was found that the calculated dose from the developed algorithm agrees very well with the measurements (mostly within 1.5%) and that a constant value for MLC transmission is insufficient to accurately predict dose for large targets and complex IMRT plans with many monitor units.

Download full-text PDF

Source
http://dx.doi.org/10.1088/0031-9155/53/3/004DOI Listing
February 2008
7 Reads

Publication Analysis

Top Keywords

mlc transmission
16
calculated dose
8
complex imrt
8
imrt fields
8
developed algorithm
8
mlc
8
dose
8
calculation algorithm
8
dose large
8
ionization chamber
8
dose calculation
8
algorithm
6
transmission
5
transmission fall-off
4
gradual mlc
4
fall-off increasing
4
off-axis distance
4
compared measured
4
measured dose
4
dose methods
4

References

(Supplied by CrossRef)

Cadman P et al.
Phys. Med. Biol. 2002

Court L E et al.
Technol. Cancer Res. Treat. 2006

Similar Publications